Essays --

The Ethics of Drug Design and Testing Victor Arce Arizona State University â€Æ' Drug Design, Testing, and Marketing The discovery of a lead pharmacophore and its subsequent testing in animals and humans has only recently taken shape thanks to the advancement in the fields of pharmacology, physiology, chemistry, and biology. Within the last 40 years, the near-linear advancement of computing power has allowed for the imaging of enzyme structures and therefore led to the ab initio calculations of structure shape and size in drug development. The recent scientific interest in biomimicry has created a new field for lead drug synthesis and treatment. The field of pharmacology is being bombarded with possible drug targets so why has the influx of drugs into the market remained relatively slow compared to all of the possible leads? The answer to that question has to do with the process by which a drug must be tested and approved before hitting markets. The process by which a treatment or a drug is studied is scientific. Figure 1- A flowchart demonstrating the process by which a drug must undergo before being marketed and regulated to the public. Figure 1 shows the process by which a drug is developed. The basis of therapies lies in the chemical, physiological understanding of disease. The study begins with a question. The question or hypothesis is based on the understanding of the human body and it’s function. The hypothesis must then be tested using reproducible methods. The compound in question is tested in vitro using a line of cells that are most relevant to the target site that the researchers are studying. For example, if you are researching a drug that could possibly target lymphomas, you would use a cell line that ... ...standard for human research ethics. The document is not legally binding to any country or entity but instead serves as a moral standard for all scientists and physicians as well as countries who want to use it as a guideline for legislation on human research in their own jurisdiction. Conducting Ethical Animal Research As seen in the first part of this paper, the use of animals in the advancement of medical knowledge can be traced back to the Romans. Galen may be one of the first historically significant scientists who used animals to further the knowledge of medicine. His vivisections led to a greater understanding of the healing process, the cardiovascular system, and digestion among other topics. By today’s standards, the vivisections that Galen carried out are seen as unethical and barbaric. The unnecessary level of pain inflicted on the animal would today be Essays -- The Ethics of Drug Design and Testing Victor Arce Arizona State University â€Æ' Drug Design, Testing, and Marketing The discovery of a lead pharmacophore and its subsequent testing in animals and humans has only recently taken shape thanks to the advancement in the fields of pharmacology, physiology, chemistry, and biology. Within the last 40 years, the near-linear advancement of computing power has allowed for the imaging of enzyme structures and therefore led to the ab initio calculations of structure shape and size in drug development. The recent scientific interest in biomimicry has created a new field for lead drug synthesis and treatment. The field of pharmacology is being bombarded with possible drug targets so why has the influx of drugs into the market remained relatively slow compared to all of the possible leads? The answer to that question has to do with the process by which a drug must be tested and approved before hitting markets. The process by which a treatment or a drug is studied is scientific. Figure 1- A flowchart demonstrating the process by which a drug must undergo before being marketed and regulated to the public. Figure 1 shows the process by which a drug is developed. The basis of therapies lies in the chemical, physiological understanding of disease. The study begins with a question. The question or hypothesis is based on the understanding of the human body and it’s function. The hypothesis must then be tested using reproducible methods. The compound in question is tested in vitro using a line of cells that are most relevant to the target site that the researchers are studying. For example, if you are researching a drug that could possibly target lymphomas, you would use a cell line that ... ...standard for human research ethics. The document is not legally binding to any country or entity but instead serves as a moral standard for all scientists and physicians as well as countries who want to use it as a guideline for legislation on human research in their own jurisdiction. Conducting Ethical Animal Research As seen in the first part of this paper, the use of animals in the advancement of medical knowledge can be traced back to the Romans. Galen may be one of the first historically significant scientists who used animals to further the knowledge of medicine. His vivisections led to a greater understanding of the healing process, the cardiovascular system, and digestion among other topics. By today’s standards, the vivisections that Galen carried out are seen as unethical and barbaric. The unnecessary level of pain inflicted on the animal would today be

Improving Management Essay

It has been established that Company Q is a small grocery chain that has recently decided to close two of their stores in heavily populated areas due to profit loss and high crime statistics. The necessity to close two stores is a significant economic failure for both the community and the stake holders involved in the franchise. Company Q has demonstrated that improvements need to be made to restore their reputation within the community and gain the confidence it needs to succeed among the share holders of the company. Since Company Q has closed these two stores, the loss of employment by members of the community has been recognized along with the need for citizens to travel further outside of the community for groceries. This takes tax revenue away from the city and has also resulted in two vacant buildings. In a community already plagued with crime, this adds to the potential of additional crime. In order to salvage Company Q’s reputation with the community and restore trust with the shareholders, significant changes will need to be made. Based on the closure of two stores, the social responsibility that Company Q exudes is very poor and concerted effort will need to be displayed in order to prove they are a socially responsible company. Part B For several years, customers of Company Q have requested that Company Q offer a more health conscience and organic variety of foods. Due to the recent closure of two stores, it is noted that there are now funds available to provide this request at the remaining open franchises. Company Q recognizes that in order to regain the customer’s trust, they need to be accommodating to the desires and needs of their customers. The first recommendation is to continue to provide the healthier, organic food varieties being requested. This action recognizes the customer’s desires and validates that Company Q is listening and wants to be accommodating.  Money that is no longer being utilized to manage the two stores that are closed can now be allocated to the high margin items at the stores that remain open. Company Q has been asked by the local food bank to donate day-old products instead of throwing it away. Company Q has denied this request citing worries about fraud and possibilities of employees stealing and stating that they were actually donating it. Our first recommendation is to rescind this policy and work with your local food bank to be able to obtain this otherwise wasted food. The reputation with the community is already fragile after the closure of two nearby stores. In order to build trust with the community and the shareholders of Company Q, simply providing the requested healthier, organic food will not be enough. Extra effort being demonstrated by Company Q will need to be recognized. The next recommendation would be to create an Action Committee within each of Company Q’s open stores. This Action Committee will work together to create a system that  monitors the amount of high margin items being purchased from the distributor and then being sold to the customer. The products that can be donated to the local food bank will be recorded. These records will be maintained by the Action Committee and preferably a member of the managerial staff. The donated product can be considered a tax write off at year end. Since there is a committee monitoring what is coming in and what is being donated out, it will help minimize the potential of fraud or possible theft by employees. This Action Committee can then determine which products are being sold on a consistent basis and which products are being donated. The purchasing of high margin items from the distributors can be adjusted so that more popular items are being sold and fewer items are being donated. This action will demonstrate to the community that Company Q cares about the citizens and they want to be an active part of the community. It also can instill trust with Company Q’s employees that they are not the reason the business wasn’t donating to the local food bank, and that they believe their employees are trusting and have integrity. A final recommendation would be for Company Q to establish their own volunteer program consisting of members of management. If additional employees of Company Q desire to be part of the volunteer committee, it is completely on a volunteer basis. This volunteer team will periodically represent Company Q at local events. They can volunteer time at the food bank, local homeless shelters, charitable events and so forth. The team can organize events to paint over graffiti in the part of town where they previously closed two of their stores. The presence of Company Q in the community can help restore trust that was lost when two stores were closed and the community suffered. The stockholders in Company Q will also see a significant change in the community’s perspective of their company. Based on these three recommendations, we believe that Company Q will exemplify the social responsibility expected by a company this size and that has such a presence in this populated community. Upon request, additional recommendations can be made to ensure Company Q sustains and improves upon its reputation with the public.

Gender, Sexual Orientation And Education - 1746 Words

In today’s society, there are divides that impede the movement of progress. These divides may disperse around a number of issues that revolve around gender, religion, sexual orientation and education. These divides have created an un-opened minded society that judge people and groups based on the prejudices and stereotypes that treat them differently. In the aspect of identity discrimination, American society plays a big role in keeping those that are different isolated from the rest of the world. Today’s society suffers huge from a spectrum that focuses power on discrimination. In this spectrum, transgender individuals are perceived as people that are most damaging than lesbians, gay men, and bisexual people. Transgendered people are†¦show more content†¦Now one might say transgendered individuals get more special treatment than any other citizen, there are some cases that support one’s theory, and there’s the cases that support transgendered peo ple being dehumanized because of who they are. Discrimination in the workplace is one of the many places that transgendered individuals become a victim to a hate crime because of their sexual orientation. Many transgenders get terminated because of their gender identity or planned transition because ones not comfortable with their lifestyle or it’s a sin to change the gender one was born with. Becoming a terminated employee because of how one present themselves to others in the workplace is an issue that majority of society does not see anything wrong with, being fired should never be based on what one does outside of work but on the performance and the quality of the work that’s being done inside on the job. Society is saying gender identity is a medical condition, human beings that are citizens and is classifying themselves as transgender do not have any way of protecting themselves from any type of targeted violence towards their safety. There is no federal law that prohibits discrimination on any